Search results for "Genetic hitchhiking"
showing 2 items of 2 documents
Founder effects drive the genetic structure of passively dispersed aquatic invertebrates
2018
Populations of passively dispersed organisms in continental aquatic habitats typically show high levels of neutral genetic differentiation, despite their high dispersal capabilities. Several evolutionary factors, including founder events and local adaptation, and life cycle features such as high population growth rates and the presence of propagule banks, have been proposed to be responsible for this paradox. Here, we have modeled the colonization process in these organisms to assess the impact of migration rate, growth rate, population size, local adaptation and life-cycle features on their population genetic structure. Our simulation results show that the strongest effect on population st…
A genome-wide view of Caenorhabditis elegans base-substitution mutation processes
2009
Knowledge of mutation processes is central to understanding virtually all evolutionary phenomena and the underlying nature of genetic disorders and cancers. However, the limitations of standard molecular mutation detection methods have historically precluded a genome-wide understanding of mutation rates and spectra in the nuclear genomes of multicellular organisms. We applied two high-throughput DNA sequencing technologies to identify and characterize hundreds of spontaneously arising base-substitution mutations in 10 Caenorhabditis elegans mutation-accumulation (MA)-line nuclear genomes. C. elegans mutation rate estimates were similar to previous calculations based on smaller numbers of m…